MECHANISMS OF MELANOMA DRUG RESISTANCE

Mechanisms of Drug Resistance

Progress of research into the problem of resistance to antibiotics is held back by lack of knowledge of the biochemical mechanisms by which these drugs act. Fortunately, it is possible to study some of the mechanisms of drug resistance, even at a biophysical or biochemical level, without necessarily knowing very much about how the drug works—just as it is possible to study (at least at a biolog...

Molecular mechanisms of drug resistance.

Mechanisms of cancer drug resistance.

The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Frequently resistance is...

Dissecting resistance mechanisms in melanoma combination therapy

quiescent and physiological autophagy interact in response to therapies. Figure 2. A. Calibrating the model with in vitro data. B. Validating model predictions with in vitro combination therapy. Abstract— We present a compartment model that explains melanoma cell response and resistance to mono and combination therapies. Model parameters were estimated by utilizing an optimization algorithm to ...

Getting around PLX4032: studies turn up unusual mechanisms of resistance to melanoma drug.

A bout half of all melanomas are driven by a mutation in the B-RAF gene, called V600 → E. So in 2009, when early small trials showed many patients with the mutation responding to a drug called PLX4032, researchers were jubilant. The drug is now in a pivotal phase III trial for metastatic melanoma; there is talk about accelerated approval; and its developers, Plexxikon and Roche, have already op...